Trevor Jeffrey Bush

Before pursuing my PhD in Pharmacology at Yale University, I completed my B.S. in Biotechnology and Biochemistry at Worcester Polytechnic Institute. Under the mentorship of Pamela Weathers, I focused on the therapeutic potential of Artemisia annua and A. afra. Using transcriptomic and proteomic techniques, I studied these plants and their secondary metabolites and derivatives for their ability to treat both infectious (e.g., tuberculosis) and non-communicable diseases (e.g., dermal fibrosis) in vitro. My work also included development of plant-based decellularized scaffolds for modeling disease in 3D.

Now, my research operates broadly in two complementary directions. First, I use a multi-omics systems biology approach that integrates transcriptomics, proteomics, and lipidomics to understand the systemic contribution of lipid composition and complex lipids in normal physiology, aging and disease. Second, I apply network pharmacology to investigate the polypharmacological and synergistic mechanisms by which natural products modulate multiple molecular targets and lipid composition simultaneously to restore tissue resilience and promote regeneration.